Our Mission

CCL is a research facility dedicated to:

I. Computational Chemodynamics and Toxicodynamics

This involves the development, computational implementation, and application/evaluation of physically and physiologically based mathematical models of chemodynamic (environmental) and toxicodynamic (biological) processes (research area of mechanistic/prognostic modeling).

II. Environmental and Biological Informatics

This involves the development and/or application of computational tools for the mining, pattern recognition, and statistical analysis/interpretation of large, multivariate, environmental and biological datasets, with emphasis on environmental indicators and toxicogenomics applications (research area of phenomenological/diagnostic modeling).

Objective of the research efforts at CCL is the improvement of procedures for:

• Predicting transport/fate and quantifying concentrations/depositions of chemicals in multimedia environments (environmental modeling).
• Estimating multiroute/multipathway exposures of individuals and populations to toxics in various indoor and outdoor microenvironments (exposure modeling).
• Estimating internal doses for appropriate target tissues, using physiologically-based transport and toxicokinetic modeling (biological dosimetry modeling).
• Optimizing the information that can be extracted from complex datasets relevant to systems that involve environment-organism interactions (enviroinformatics and bioinformatics).

CCL's efforts include exploring computer simulation-based alternatives to animal testing for risk assessment.

EOHSI is a Joint Institute of the University of Medicine & Dentistry of NJ – Robert Wood Johnson Medical School and Rutgers University

Questions or comments? Contact Webmaster. Last updated February 18, 2004